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Rescued Lamc2 KO mice appear normal at birth and live to adulthood.
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posted on 2013-02-19, 23:15 authored by Tracy L. Adair-Kirk, Gail L. Griffin, Michelle J. Meyer, Diane G. Kelley, Jeffrey H. Miner, Douglas R. Keene, M. Peter Marinkovich, J. Michael Ruppert, Jouni Uitto, Robert M. SeniorImages of newborn Lamc2 Het (A), Lamc2 KO (B), rescued Lamc2 KO (C), and Lamc2 WT (D), and adult Lamc2 WT (E) and rescued Lamc2 KO (F) are shown. Newborn Lamc2 KO mice are occasionally smaller, have blistered feet (arrow), and a smaller milk pouch (B). Lamc2 KO mice that carry both the K14-rtTA and TetO-HuLamC2 transgenes (C) look similar to littermate controls (A and D). Rescued Lamc2 KO mice live to adulthood (F) and have similar length and weight as Lamc2 WT littermates (E).
