Rescued <i>Lamc2</i> KO mice appear normal at birth and live to adulthood.
figure
posted on 2013-02-19, 23:15 authored by Tracy L. Adair-Kirk, Gail L. Griffin, Michelle J. Meyer, Diane G. Kelley, Jeffrey H. Miner, Douglas R. Keene, M. Peter Marinkovich, J. Michael Ruppert, Jouni Uitto, Robert M. Senior<p>Images of newborn <i>Lamc2</i> Het (A), <i>Lamc2</i> KO (B), rescued <i>Lamc2</i> KO (C), and <i>Lamc2</i> WT (D), and adult <i>Lamc2</i> WT (E) and rescued <i>Lamc2</i> KO (F) are shown. Newborn <i>Lamc2</i> KO mice are occasionally smaller, have blistered feet (arrow), and a smaller milk pouch (B). <i>Lamc2</i> KO mice that carry both the K14-rtTA and TetO-HuLamC2 transgenes (C) look similar to littermate controls (A and D). Rescued <i>Lamc2</i> KO mice live to adulthood (F) and have similar length and weight as <i>Lamc2</i> WT littermates (E).</p>
