The effect of GYS1 genotype on skeletal muscle histopathology.
figure
posted on 2013-02-20, 01:39 authored by Rosie J. Naylor, Leanda Livesey, John Schumacher, Nicole Henke, Claire Massey, Kenny V. Brock, Marta Fernandez-Fuente, Richard J. Piercya–d: Boxplots illustrating the percentage of muscle fibres containing (a) internalised nuclei, (b) subsarcolemmal vacuoles, (c) cytoplasmic inclusions and (d) diastase resistant inclusions in horses homozygous (HH) and heterozygous (HR) for GYS1 mutation and controls (RR). * Denotes significant differences between individual groups (p<0.05), ** (p<0.01), following post- hoc analysis. e–h: Representative images of the pathology (arrows) identified (e) internalized nuclei, (f) subsarcolemmal vacuoles, (g) cytoplasmic inclusions and (h) diastase resistant inclusions (e–g: haematoxylin and eosin; h: Periodic acid Schiff following diastase digestion). Bar = 50 µm.
